How would I describe a group of patients similar to mine?
What is the condition or disease you are interested in?
Which main intervention, prognostic factor, or exposure am I considering?
What do you want to do with this patient (e.g. treat, diagnose, observe)?
What is the alternative to the intervention (e.g. placebo, different drug, surgery)?
What is the main alternative to compare with the intervention?
What are the relevant outcomes (e.g. morbidity, death, complications)?
What can I hope to accomplish, measure, improve, or affect?